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MM308 Molecular Basis of Diseases 2
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Module Introduction
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Module Synopsis
Module Guide: Molecular Basis of Disease II
Student Learning Time
About Prof Dr. Ong Chin Eng
About Dr. Koh Rhun Yian
About Dr. Lim Lay Cheng
About Dr. Hazwanie Hashim
Introduce Yourself
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General Discussion
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Marking rubric for case study
Topic 1: Introduction to molecular basis of diseases 2
Topic 1: Lecture Note: Introduction to Molecular Basis of Diseases II
Topic 1: Video: G-protein Coupled Receptors (GPCRs)
Topic 1: Video: Medical Genomics in Clinical Practice
Topic 1: Video: What is Precision Medicine?
Topic 1: Video: The Problem And Promise Of Precision Medicine
Topic 2: Molecular basis of gastrointestinal diseases
Topic 2: Video: Immunology in Human Gut
Topic 2: Video: Ulcerative Colitis
Topic 2: Video: Crohn's Disease
Topic 2: Video: Peptic Ulcer
Topic 2: i-Lecture: Pathogenesis of Irritable Bowel Diseases
Topic 2: i-Lecture: Treatment for Irritable Bowel Diseases
Topic 2: i-Lecture: Pathogenesis of Peptic Ulcers
Topic 2: i-Lecture: Treatment for Peptic Ulcers and Acid-related Disorders
Topic 2: Lecture Note: Molecular Basis of Gastrointestinal Diseases
Topic 2: Further Reading: Articles
Topic 2: Quiz: Molecular Basis of Gastrointestinal Diseases
Topic 2: Discussion for Molecular Basis of Gastrointestinal Disorders (2023)
Topic 3: Molecular basis of respiratory diseases
Topic 3: Lecture note: molecular basis of respiratory diseases
Topic 3: i-lecture: molecular basis of respiratory diseases
Video: H1N1 Virus
Video: Flu attack
Topic 3: Further reading: Articles and Videos
Topic 3: Discussion for the Molecular Basis of Respiratory Diseases
Topic 4: Molecular basis of immune diseases'
Topic 4: i-Lecture: Autoimmunity
Topic 4: i-Lecture: Severe Combined Immune Deficiency (SCID)
Topic 4: i-Lecture: HIV and AIDS
Topic 4: Lecture Note: Molecular Basis of Immune Diseases
Topic 4: Video: SCID - A Family's Journey Through Isolation
Topic 4: Video: Gene Therapy for X-linked SCID
Topic 4: Video: HIV Life Cycle
Topic 4: Video: HIV Vaccine Approach Succeeds in First Clinical Trial
Topic 4: Further Reading: Articles
Topic 4: Quiz: Molecular Basis of Immune Diseases
Topic 4: Discussion on the Molecular Basis of Immune Diseases (2024)
Topic 5: Molecular basis of diabetes
Topic 5: Video: Diabetes and the body
Topic 5: Lecture Note: Molecular Basis of Diabetes
Topic 5: iLecture: Molecular Basis of Diabetes - T1DM
Topic 5: Molecular Basis of Diabetes - MS Stream Version
Topic 5: Video: Molecular Basis: Insulin Signaling
Topic 5: Video: Molecular Basis: AKT signaling pathway
Topic 5: Reading: Insulin Resistance
Topic 5: Reading: Diabetes - Perspectives in Drug Therapy
Topic 5: Reading: Animal models in diabetes research
Topic 5: Further Reading: Articles/Books
Topic 5: Case Study: Topic and Guidelines
Topic 5: Submission: Case Study Report on Diabetes
Topic 5: Case Study Submission on Diabetes
Topic 6: Molecular basis of other endocrine diseases
Video 1: Overview of endocrine diseases
Video 2: Introduction to adrenal disease
Video 3: Introduction to Cushing's syndrome disease
Video 4: Pathophysiology of Cushing syndrome
Lecture note: Molecular endocrine disorders
Article 1: Molecular basis of disease
Article 2: Endocrinopathies
Article 3: Advances in the medical treatment of Cushings syndrome
Topic 6: Discussion on Molecular Basis of Endocrine Disorders
Topic 7: Molecular basis of cancer
Topic 7: Lecture Note: Molecular Basis of Cancer
Topic 7: Video: Molecular Basis of Cancer Part I
Topic 7: i-Lecture: Molecular Basis of Cancer Part II
Topic 7 - Video: Molecular Basis of Cancer Part III
Topic 7: Further Reading: Articles
Topic 7: Reading: Oxford Textbook of Oncology (3rd Ed)
Topic 7: Reading: Oxford Textbook of Medicine (5 edn)
Topic 7: Case Study: Molecular Basis of Cancer
Topic 7: Discussion: Forum for Molecular Basis of Cancer
Topic 7: Submission: Cancer Case Study Report
Topic 8: Trends in post-genomic era
Lecture Slides: Trends in Post-Genomic Era
Milestone in Genomic Sequencing
Fact Sheet: The Human Genome Project (HGP)
Telomere-to-Telomere (T2T) Consortium
Shotgun Sequencing
A Haplotype Map of the Human Genome
Illumina sequencing by synthesis
RNA interference (RNAi): By Nature video
Genome editing with CRISPR-Cas9
What Is a Genome and Why Do We Care?
What Was the First Human Genome Looks Like?
What Lessons did we Learn from the Human Genome Project?
How Can We Use Genomes to Understand the Healthy Body and Fight Diseases?
What is the value of Precision Medicine?
What are the Ethical Issues Related to Genomic and Precision Medicine?
The problem and promise of precision medicine - TIME
Cancer Immunotherapy
What Is Bioinformatics?
How Big Data Could Transform The Health Care Industry
Data Science And Genetics - biomedical big data revolution
Data science and cancer - what do cancer and data science in common?
A Data Sharing Platform to Promote Precision Oncology: The Genomic Data Commons
Bold Prediction #1: Generating and analyzing a complete human genome sequence will be routine for any research laboratory, becoming as straightforward as carrying out a DNA purification.
Bold Prediction #2: The biological function(s) of every human gene will be known; for non-coding elements in the human genome, such knowledge will be the rule rather than the exception.
Bold Prediction #3: The biological function(s) of every human gene will be known; for non-coding elements in the human genome, such knowledge will be the rule rather than the exception.
Bold Prediction #4: Research in human genomics will have moved beyond population descriptors based on historic social constructs such as race.
Bold Prediction #5: Studies involving analyses of genome sequences and associated phenotypic information for millions of human participants will be regularly featured at school science fairs.
Bold Prediction #6: The regular use of genomic information will have transitioned from boutique to mainstream in all clinical settings, making genomic testing as routine as complete blood counts (CBCs).
Bold Prediction #7: The clinical relevance of all encountered genomic variants will be readily predictable, rendering the diagnostic designation “variant of uncertain significance (VUS)” obsolete.
Bold Prediction #8: A person’s complete genome sequence along with informative annotations can be securely and readily accessible on their smartphone.
Topic 8: Discussion forum on trends in post-genomic era
Recorded TEAMS Lecture - Nov 2022
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MM308 Molecular Basis of Diseases 2
Coordinator:
HAZWANIE BINTI HASHIM
Coordinator:
DINESH KUMAR CHELLAPPAN
Coordinator:
SOOK YEE GAN
Coordinator:
KET LI HO
Coordinator:
RHUN YIAN KOH
Coordinator:
LAY CHENG LIM
Coordinator:
CHIN ENG ONG
Coordinator:
ENG LAI TAN
